As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics.
Section on Molecular Diagnostics and Genetics contains nine chapters that focus on emerging issues and techniques.
Highly-respected author team includesthree editors who are well known in the clinical chemistry world.
Reference values in the appendix give you one location for comparing and evaluating test results.
Companion Evolve website includes appendix material and book references linked to PubMed.
Selection and Analytical Evaluation of Methods - With Statistical Techniques
Clinical Evaluation of Methods
Evidence Based Laboratory Medicine
Establishment and Use of Reference Values
Preanalytical Variables and Biological Variation
Specimen Collection and Processing
Section II: Analytical Techniques and Instrumentation
Principles of Basic Techniques and Laboratory Safety
Electrochemistry and Chemical Sensors
Chromatography and Extraction
Enzyme and Rate Analyses
Principles of Immunochemical Techniques
Nucleic Acid Techniques
Microfabrication and Microfluidics and Their Application to Clinical Diagnostics
Automation in the Clinical Laboratory
Section III: Analytes
Amino Acids, Peptides, and Proteins
Enzymes of the Red Blood Cell
Kidney Function Tests
Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors
Electrolytes and Blood Gases
Catecholamines and Serotonin
Vitamins and Trace Elements
Hemoglobin, Iron, and Bilirubin
The Porphyrias and Other Disorders of Porphyrin Metabolism
Therapeutic Drugs and Their Management
Section IV: Molecular Diagnostics and Genetics
Principles of Molecular Biology
Genomes and Nucleic Acid Alterations
Nucleic Acid Isolation
Molecular Methods in Diagnosis and Monitoring of Infectious Diseases
Plasma Nucleic Acids
Section V: Pathophysiology
Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
Gastrointestinal and Pancreatic Diseases
Disorders of Bone and Mineral Metabolism
Pituitary Function and Pathophysiology
The Adrenal Cortex
The Thyroid: Pathophysiology and Thyroid Function Testing
Reproductive Endocrinology and Related Disorders
Pregnancy and its Disorders
Newborn Screening and Inborn Errors of Metabolism
Section VI: Appendix
Reference Information for the Clinical Laboratory
By Carl A. Burtis, PhD, Health Services Division, Oak Ridge National Laboratory, Oak Ridge, TN, and Clinical Professor of Pathology, University of Utah School of Medicine, Salt Lake City, UT; Edward R. Ashwood, MD, Professor of Pathology, University of Utah School of Medicine, and President and CEO, ARUP Laboratories, Salt Lake City, UT and David E. Bruns, MD, Professor of Pathology, University of Virginia School of Medicine, Director of Clinical Chemistry and Associate Director of Molecular Diagnostics, University of Virginia Health System, Charlottesville, VA, and Former Editor, Clinical Chemistry, Washington, DC
276 x 216 (8 1/2 x 10 7/8)
New to this Edition
NEW!Two-color design throughout highlights important features, illustrations, and content for a quick reference.
NEW!Chapter on hemostasis provides you with all the information you need to accurately conduct this type of clinical testing.
NEW!Six associate editors, Ann Gronowski, W. Greg Miller, Michael Oellerich, Francois Rousseau, Mitchell Scott, and Karl Voelkerding,lend even more expertise and insight to the reference.
NEW!Reorganized chapters ensure that only the most current information is included.