Reader-friendly Cell Biology, 4th Edition, provides a concise but comprehensive foundation for students entering research or health care career paths. Award winning illustrations help readers quickly grasp general principles. The authors have thoroughly updated this popular text to provide readers with the current understanding of the principles of normal cellular function along with examples of how molecular defects predispose to human disease. Major new themes in the 4th edition include the roles of intrinsically disordered polypeptides and phase separation in cellular functions, the influence of new molecular structures on understanding mechanisms, and the impact of exciting new methods-from single cell RNA sequencing to second generation super resolution fluorescence microscopy-on advancing our understanding.
Key Features
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Clear, readable explanations provide a concise story about how cells function at the molecular level.
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An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology.
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Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases.
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Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation.
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Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death.
| ISBN | 9780323758024 |
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| Product Format | Ebook |
| Publication Date | 2022 |
| Author Information | By Thomas D. Pollard, MD, Sterling Professor, Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT; William C. Earnshaw, PhD, FRS, Professor and Wellcome Trust Principal Research Fellow, Wellcome Trust Centre for Cell Biology, ICB, University of Edinburgh, Scotland, United Kingdom; Jennifer Lippincott-Schwartz, PhD, Group Leader, Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, Virginia, United States and Graham Johnson, MA, PhD, CMI, Director, Animated Cell, Allen Institute for Cell Biology, Seattle, Washington;, QB3 Faculty Fellow, University of California, San Francisco, San Francisco, California |
| Table of Content | Front Matter/Back Matter/Section Openers 1 Introduction to Cells 2 Evolution of Life on Earth 3 Molecules: Structures and Dynamics 4 Biophysical Principles 5 Macromolecular Assembly 6 Research Strategies 7 Chromosome Organization 8 DNA Packaging in Chromatin and Chromosomes 9 Nuclear Structure and Dynamics 10 Gene Expression 11 Eukaryotic RNA Processing 12 Protein Synthesis and Folding 13 Membrane Structure and Dynamics 14 Membrane Pumps 15 Membrane Carriers 16 Membrane Channels 17 Membrane Physiology 18 Posttranslational Targeting of Proteins 19 Mitochondria, Chloroplasts, Peroxisomes 20 Endoplasmic Reticulum 21 Mechanisms of Vesicular Trafficking 22 Secretory Membrane System and Golgi Appartus 23 Endocytosis and Endosomal Membrane System 24 Processing and Degradation of Cellular Components 25 Plasma Membrane Receptors 26 Protein Hardware for Signaling 27 Second Messengers 28 Integration of Signals 29 Cells of the Extracellular Matrix and Immune System 30 Extracellular Matrix Molecules 31 Cellular Adhesion 32 Intercellular Junctions 33 Connective Tissues 34 Actin and Actin-Binding Proteins 35 Microtubules and Centrosomes 36 Intermediate Filaments 37 Motor Proteins 38 Intracellular Motility 39 Cellular Motility 40 Muscles 41 Introduction to the Cell Cycle 42 G1 Phase and Regulation of Cell Proliferation 43 S Phase and DNA Replications 44 G2 Phase, Responses to DNA Damage, and Control of Entry into Mitosis 45 Mitosis 46 Cytokinesis 47 Meiosis 48 Programmed Cell Death Cell SnapShots |
| Publication Date | 13-12-2022 |
| deltacomm1code | Electronic Book |
