Channelopathies of the Nervous System

Author
Edited by Michael R. Rose, BSc, MD, FRCP and Robert C. Griggs, MD, FACP, FAAN
ISBN
9780750645072
Publication Date
15-05-2001
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* A timely and unique reference focusing on the rapidly developing field of channelopathies of the nervous system from brain to muscle
* Written specifically for the clinical neurologist and neuroscientist
* Reviews the scientific principles of ion channel function and the clinical manifestations of the ion channel dysfunction
* A unique reference focusing on the rapidly developing field of channelopathies of common neurological disorders * Written specifically for the clinical neurologist and neuroscientist * It reviews the underlying scientific principles of ion channel function and the current research and its clinical applications
ADDITIONAL INFORMATION
ISBN 9780750645072
Author Informaiton Edited by Michael R. Rose, BSc, MD, FRCP, Consultant and Honorary Senior Lecturer in Neurology, King's Neurosciences Centre, King's College Hospital, and Guy's, St Thomas' and King's College School of Medicine and Dentistry, London, UK and Robert C. Griggs, MD, FACP, FAAN, Professor of Neurology, Pediatrics, Pathology and Laboratory Medicine; Center for Human Experimental Therapeutics; University of Rochester School of Medicine and Dentistry; Rochester, New York
Pp Authortext Rose & Griggs
Table of Content Part 1: Basic science (physiology, molecular biology and pharmacology): Physiology of ion channels; Molecular biology of ion channels; Pharmacology of ion channels; Part 2 Assessment of channel function (in vitro and in vivo): Techniques for assessing ion channel function; in vitro; Neurophysiological investigation of channelopathies in vivo; Part 3: Channel gene expression, and distribution and its relationship to disease and normal development: Plasticity of ion channel gene expression as a substrate for channelopathies; The role and consequences of ion channel distribution and dysfunction in pain; The role of ion channel distribution, dysfunction and gene expression in demyelinating disease; Part 4: Neuromuscular channel gene disorders (genetic): Chloride and sodium channel myotonias; The periodic paralyses: hyperkalaemic and hypokalaemic paralysis; Malignant hyperthermia; Acetylcholine receptor channelopathies and other congenital myasthenic syndromes; Part 5: Neuromuscular channel disorders (acquired): Myasthenia gravis and the Lambert Eaton syndrome; Autoimmune neuromyotonia; Part 6: Central nervous system channel disorders: Periodic and progressive ataxias; Epilepsies; Paroxysmal movement disorders as channelopathies; Hyperekplexia; Migraine: a multifactorial, neurovascular episodic channelopathy?; Part 7: Toxin-induced channel disorders: Ciguatera (fish poisoning); Part 8: Potential channel disorders: Potential channelopathies: selected myotonic disorders - Schwartz Jampel syndrome (SJS), myotonic dystrophy (DM), myotonic dystrophy type-2 (DM-2), proximal myotonic myopathy (PROMM) and proximal myotonic dystrophy (PDM); Andersen's syndrome; Part 9: Conclusion;
Imprint Butterworth-Heinemann
Publication Date 15-05-2001
Pages 347
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