Clinical Immunology, 6th Edition
Key Features
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Includes extensive revisions that reflect rapidly expanding research and clinical advances, including breakthrough drug and immunotherapies such as immune checkpoint inhibitors, immunotherapies for cancer, precision medicine, and transfusion medicine.
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Contains new chapters on COVID-19, immune responses, and the role of the immune system; immunoregulatory deficiencies; immune checkpoints; CAR T-cells, including new cellular-based immunotherapy; gene therapy, including CRISPR and gene selection; and a clinically-focused chapter on asthma.
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Provides new genetics content focused on data applications.
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Addresses notable advances in key areas such as the importance of the microbiota to normal immune system development and to the pathogenesis of immunologic and inflammatory diseases; relationships between the innate and adaptive immune systems; progress in rapid and cost-effective genomics; cell signaling pathways and the structure of cell-surface molecules; and many more.
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Covers hot topics such as the role of genetics and genomics in immune response and immunologic disease, atherosclerosis, recurrent fever syndromes, aging and deficiencies of innate immunity, the role of microbiota in normal immune system development and the pathogenesis of immunologic and inflammatory diseases, and novel therapeutics.
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Features a user-friendly format with color-coded boxes highlighting critical information on Key Concepts, Clinical Pearls, Clinical Relevance, and Therapeutic Principles.
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Summarizes promising research and development anticipated over the next 5-10 years with "On the Horizon" boxes and discussions of translational research.
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Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
| ISBN | 9780702081651 |
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| Author Information | Edited by Robert R. Rich, MD, Professor of Medicine and Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA; Thomas A. Fleisher, MD, FAAAAI, FACAAI, Adjunct Professor of Pediatrics, USUHA, Chief, Department of Laboratory Medicine, NIH Clinical Center, National Institutes of Health, Bethesda MD, USA; Harry W. Schroeder Jr., II, MD, PhD, Professor of Medicine, Microbiology, and Genetics, Division of Clinical Immunology and Rheumatology, Director, UAB Program in Immunology, University of Alabama at Birmingham, Birmingham, AL, USA; Cornelia M. Weyand, MD, PhD, Professor of Medicine, Stanford University School of Medicine, Department of Medicine: Immunology and Rheumatology, Stanford, CA, USA ; David B. Corry and Jennifer M. Puck |
| Table of Content | 1 The human immune response 2 Organization of the immune system 3 Innate immunity 4 Antigen receptor genes, gene products, and co-receptors/ 5 The major histocompatibility complex 6 Antigens and Antigen Presentation 7 B-cell development and differentiation 8 Immunoglobulin Function 9 T-Cell Development 10 T-Cell Activation and Tolerance 11 Helper T-Cell Subsets and Control of the Inflammatory Response 12 Cytotoxic T Lymphocytes and Natural Killer Cells? 13 Regulatory Immune Cells 14 Cytokines and cytokine receptors 15 Chemokines and chemokine receptors 16 Lymphocyte adhesion and trafficking 17 Death Pathways and Immunogenicity 18 T-cell activation and tolerance 18 Regulated cell death 18 The Microbiota in Immunity and Inflammation 18 Human Genomics in Immunology 19 Regulatory RNA in Immunologic Diseases 20 Immunometabolism 21 Immune Deficiencies at the Extremes of Age 22 Nutritional Modulation of Immune Function 22 The Microbiota in Immunity and Inflammation 23 Immunology of the Skin 24 Immunology of Mucosal Surfaces 24 Complement in host deficiencies and diseases 24 Phagocyte deficiencies 24 Mast cells, basophils, and mastocytosis 24 Eosinophils and eosinophilia 25 Host defenses to viruses 26 Host defenses to intracellular bacteria 27 Host defenses to extracellular bacteria including Spirochetes 28 Host Defenses to Fungi 29 Host defenses to spirochetes 29 Host defenses to protozoa 30 Host defenses to helminth infections 31 Emerging Pandemic Infectious Disease Threats 32 Approach to the Evaluation of the Patient with Suspected Immunodeficiency 33 Human Genomics in Immunology 33 Primary antibody deficiencies 34 Primary T-cell immunodeficiencies 35 Genetic disorders of IFNs-, IL-17, IL-18 and NF-?B-mediated immunity 36 Hemophagocytic Lymphohistiocytosis 37 Autoinflammatory Syndromes 38 Immune Activation Disorders 39 Neutrophils and Neutrophil Disorders 40 Complement and Complement Disorders 41 Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome 42 Autoantibody Mediated Phenocopies of Primary Immunodeficiency Diseases 43 Allergic Airway Disease 44 Mast Cells and Mast Cell Disorders 45 Eosinophils and Eosinophilic Disorders 46 Urticaria, angioedema, and anaphylaxis¡ 47 Allergic reactions to stinging and biting insects 48 Atopic and contact dermatitis 49 Food allergy 50 Drug Hypersensitivity 51 Allergic disorders of the eye 51 Drug hypersensitivity 51 Occupational Respiratory Allergies 51 Mechanisms of autoimmunity 52 Systemic lupus erythematosus 53 Rheumatoid arthritis 54 Juvenile idiopathic arthritis 55 Sjögren syndrome 56 Scleroderma-systemic sclerosis 57 Inflammatory muscle diseases 58 Spondyloarthritis 59 Small and medium vessel primary vasculitis 60 Large-vessel vasculitides 61 Systemic autoinflammatory syndromes 61 Antiphospholipid syndrome 62 Immunohematologic disorders 63 Bullous diseases of the skin and mucous membranes 64 Immunology of psoriasis 65 Myasthenia gravis 66 Multiple sclerosis 67 Autoimmune peripheral neuropathies 68 Immunologic renal diseases 69 Immunologic Diseases of the Cardiovascular System 70 Autoimmune thyroid diseases 71 Type 1 Diabetes 72 Immunologic lung diseases 73 Chronic Obstructive Pulmonary Disease and Emphysema 74 Immunologic ocular disease 75 Immunologic diseases of the gastrointestinal tract 76 Inflammatory hepatobiliary diseases 77 Tumor immunotherapy 77 Lymphoid leukemias 78 Lymphomas 79 Monoclonal gammopathies 80 Immune Responses to Solid Tumors and Immune Checkpoint tTerapy 81 CAR T-Cell Therapy 82 Immunoglobulin Therapy: Replacement and Immunomodulation 83 Glucocorticoids 84 Immunomodulating Drugs 85 Protein Kinase Antagonists 86 Biologic Response Modifiers 87 Vaccines 88 Allergen Immunotherapy of Allergic Disease 89 Solid Organ Transplantation: Rejection, Immunosuppression and Tolerance 89 Immune Checkpoint Therapy 90 Allogeneic Transplantation for Immunodeficiency 91 Gene Therapy fo Primary Immune deficiency Diseases 92 Hematopoietic Stem Cell Transplantation for Malignant Diseases 93 Flow cytometry 94 Biological Modifiers of Inflammation 94 Vaccines 94 Immunotherapy of allergic disease 94 Assessment of Functional Immune Responses in Lymphocytes 95 Assessment of neutrophil function 96 Assessment of human allergic diseases App1 - Selected CD molecules and their characteristics App2 - Laboratory reference values 98 Molecular methods 98 A3: Vaccine schedules |
| Publication Date | 01-09-2022 |
| Pages | 1326 |
| Trim | 276 x 216 (8 1/2 x 10 7/8) |
| Stock Status | Coming Soon |
| deltacomm1code | Books |
