Offering unique, comprehensive coverage of both basic science and clinical scenarios, Clinical Immunology: Principles and Practice, 6th Edition, brings you up to date with every aspect of this fast-changing field. It examines the molecular, cellular, and immunologic bases of immunologic diseases and their broader systemic implications; it also includes complete coverage of common and uncommon immunologic disorders. Updated with all the latest immunologic research and clinical implications, including breakthrough immunotherapies and molecular-based treatment protocols, this fully revised edition provides authoritative guidance from some of the most respected global leaders in immunology in one complete, well-illustrated volume.
Key Features
- Includes extensive revisions that reflect rapidly expanding research and clinical advances, including breakthrough drug and immunotherapies such as immune checkpoint inhibitors, immunotherapies for cancer, precision medicine, and transfusion medicine.
- Contains new chapters on COVID-19, immune responses, and the role of the immune system; immunoregulatory deficiencies; immune checkpoints; CAR T cells, including new cellular-based immunotherapy; gene therapy, including CRISPR and gene selection; and a clinically focused chapter on asthma.
- Provides new genetics content focused on data applications.
- Addresses notable advances in key areas such as the importance of the microbiota to normal immune system development and to the pathogenesis of immunologic and inflammatory diseases; relationships between the innate and adaptive immune systems; progress in rapid and cost-effective genomics; cell signaling pathways and the structure of cell-surface molecules; and many more.
- Covers hot topics such as the role of genetics and genomics in immune response and immunologic disease, atherosclerosis, recurrent fever syndromes, aging and deficiencies of innate immunity, the role of microbiota in normal immune system development and in the pathogenesis of immunologic and inflammatory diseases, and novel therapeutics.
- Features a user-friendly format with color-coded boxes highlighting critical information on Key Concepts, Clinical Pearls, Clinical Relevance, and Therapeutic Principles.
- Summarizes promising research and development anticipated over the next 5-10 years with "On the Horizon" boxes and discussions of translational research.
- An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
| ISBN | 9780702081651 |
|---|---|
| Product Format | Book |
| Publication Date | 2022 |
| Author Information | Edited by Robert R. Rich, MD, Professor of Medicine and Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA; Thomas A. Fleisher, MD, FAAAAI, FACAAI, Adjunct Professor of Pediatrics, USUHA, Chief, Department of Laboratory Medicine, NIH Clinical Center, National Institutes of Health, Bethesda MD, USA; Harry W. Schroeder Jr., II, MD, PhD, Professor of Medicine, Microbiology, and Genetics, Division of Clinical Immunology and Rheumatology, Director, UAB Program in Immunology, University of Alabama at Birmingham, Birmingham, AL, USA; Cornelia M. Weyand, MD, PhD, Professor of Medicine, Stanford University School of Medicine, Department of Medicine: Immunology and Rheumatology, Stanford, CA, USA ; David B. Corry and Jennifer M. Puck |
| Table of Content | PART I Principles of Immune Response 1 The Human Immune Response 2 Organization of the Immune System 3 Innate Immunity 4 Antigen Receptor Genes, Gene Products, and Co-Receptors 5 The Major Histocompatibility Complex 6 Antigens and Antigen Presentation 7 B-Cell Development and Differentiation 8 Immunoglobulin Function 9 T-Cell Development 10 T-Cell Activation and Tolerance 11 Helper T-Cell Subsets and Control of the Inflammatory Response 12 Cytotoxic T Lymphocytes and Natural Killer Cells 13 Regulatory Immune Cells 14 Cytokines and Cytokine Receptors 15 Chemokines and Chemokine Receptors 16 Lymphocyte Adhesion and Trafficking 17 Death Pathways and Immunogenicity PART II Fundamentals of Host-Environmental Interactions 18 Human Genomics in Immunology 19 Regulatory RNA in Immunologic Diseases 20 Immunometabolism 21 Immune Deficiencies at the Extremes of Age 22 The Microbiota in Immunity and Inflammation PART III Host Defenses to Infectious Agents 23 Immunology of the Skin 24 Immunology of Mucosal Surfaces 25 Host Defenses to Viruses 26 Host Defenses to Intracellular Bacteria 27 Host Defenses to Extracellular Bacteria, Including Spirochetes 28 Host Defenses to Fungi 29 Host Defenses to Protozoa 30 Host Defenses to Helminth Infection 31 Emerging Pandemic Infectious Disease Threats PART IV Immune Deficiency and Immune Regulatory Disorders 32 Approach to the Evaluation of the Patient With Suspected Immunodeficiency 33 Primary Antibody Deficiencies 34 Primary T-Cell Immunodeficiencies 35 Genetic Disorders of Interferons-, Interleukin-17, Interleukin-18, and Nuclear Factor-?B-Mediated Immunity 36 Hemophagocytic Lymphohistiocytosis 37 Autoinflammatory Syndromes 38 Immune Regulatory Disorders 39 Neutrophils and Neutrophil Disorders 40 Complement and Complement Disorders 41 Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome 42 Autoantibody-Mediated Phenocopies of Primary Immunodeficiency Diseases PART V Allergic Diseases 43 Allergic Airway Diseases 44 Mast Cells and Mast Cell Disorders 45 Eosinophils and Eosinophilic Disorders 46 Urticaria, Angioedema, and Anaphylaxis 47 Allergic Reactions to Stinging and Biting Insects 48 Atopic and Contact Dermatitis 49 Food Allergy 50 Drug Hypersensitivity PART VI Systemic Immune Diseases 51 Mechanisms of Autoimmunity 52 Systemic Lupus Erythematosus 53 Rheumatoid Arthritis 54 Juvenile Idiopathic Arthritis 55 Sjögren's Syndrome 56 Scleroderma-Systemic Sclerosis 57 Inflammatory Muscle Diseases 58 Spondyloarthritis 59 Small- and Medium-Vessel Primary Vasculitis 60 Large Vessel Vasculitides 61 Antiphospholipid Syndrome PART VII Organ-Specific Inflammatory Disease 62 Immunohematologic Disorders 63 Bullous Diseases of the Skin and Mucous Membranes 64 Immunology of Psoriasis 65 Myasthenia Gravis 66 Multiple Sclerosis 67 Autoimmune Peripheral Neuropathies 68 Immunologic Renal Diseases 69 Immunologic Mechanisms of Atherosclerosis and Myocarditis 70 Autoimmune Thyroid Diseases 71 Type 1 Diabetes 72 Immunologic Lung Diseases, 919 73 Chronic Obstructive Pulmonary Disease and Emphysema 74 Immunologic Ocular Disease 75 Immunologic Diseases of the Gastrointestinal Tract 76 Inflammatory Hepatobiliary Diseases PART VIII Immunology and Immunotherapy of Neoplasia 77 Lymphoid Leukemias 78 Lymphomas 79 Monoclonal Gammopathies 80 Immune Responses to Solid Tumors and Immune Checkpoint Therapy 81 CAR T-Cell Therapy PART IX Medical Management of Immunological Diseases 82 Immunoglobulin Therapy: Replacement and Immunomodulation 83 Glucocorticoids 84 Immunomodulating Drugs 85 Protein Kinase Antagonists 86 Biologic Response Modifiers 87 Vaccines 88 Allergen Immunotherapy for Allergic Diseases PART X Transplantation 89 Solid Organ Transplantation: Rejection, Immunosuppression, and Tolerance 90 Allogeneic Transplantation for Immunodeficiency 91 Gene Therapy for Primary Immune Deficiency Diseases 92 Hematopoietic Stem Cell Transplantation for Malignant Diseases PART XI Diagnostic Immunology 93 Flow Cytometry 94 Assessment of Functional Immune Responses in Lymphocytes 95 Assessment of Neutrophil Function 96 Assessment of Human Allergic Diseases Appendix 1: Selected CD Molecules and Their Characteristics Appendix 2: Laboratory Reference Values Index |
| Publication Date | 06-12-2022 |
| Pages | 1326 |
| Trim | 276 x 216 (8 1/2 x 10 7/8) |
| Stock Status | Coming Soon |
| deltacomm1code | Books |
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