Clinical Immunology E-Book, 6th Edition

Edited by Robert R. Rich, MD, Thomas A. Fleisher, MD, FAAAAI, FACAAI, Harry W. Schroeder Jr., II, MD, PhD, Cornelia M. Weyand, MD, PhD, David B. Corry and Jennifer M. Puck
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Offering unique, comprehensive coverage of both basic science and clinical scenarios, Clinical Immunology: Principles and Practice, 6th Edition, brings you up to date with every aspect of this fast-changing field. It examines the molecular, cellular, and immunologic bases of immunologic diseases and their broader systemic implications; it also includes complete coverage of common and uncommon immunologic disorders. Updated with all the latest immunologic research and clinical implications, including breakthrough immunotherapies and molecular-based treatment protocols, this fully revised edition provides authoritative guidance from some of the most respected global leaders in immunology in one complete, well-illustrated volume.

Key Features
  • Includes extensive revisions that reflect rapidly expanding research and clinical advances, including breakthrough drug and immunotherapies such as immune checkpoint inhibitors, immunotherapies for cancer, precision medicine, and transfusion medicine.
  • Contains new chapters on COVID-19, immune responses, and the role of the immune system; immunoregulatory deficiencies; immune checkpoints; CAR T cells, including new cellular-based immunotherapy; gene therapy, including CRISPR and gene selection; and a clinically focused chapter on asthma.
  • Provides new genetics content focused on data applications.
  • Addresses notable advances in key areas such as the importance of the microbiota to normal immune system development and to the pathogenesis of immunologic and inflammatory diseases; relationships between the innate and adaptive immune systems; progress in rapid and cost-effective genomics; cell signaling pathways and the structure of cell-surface molecules; and many more.
  • Covers hot topics such as the role of genetics and genomics in immune response and immunologic disease, atherosclerosis, recurrent fever syndromes, aging and deficiencies of innate immunity, the role of microbiota in normal immune system development and in the pathogenesis of immunologic and inflammatory diseases, and novel therapeutics.
  • Features a user-friendly format with color-coded boxes highlighting critical information on Key Concepts, Clinical Pearls, Clinical Relevance, and Therapeutic Principles.
  • Summarizes promising research and development anticipated over the next 5-10 years with "On the Horizon" boxes and discussions of translational research.
ISBN 9780702081668
Product Format Ebook
Publication Date 2022
Author Information Edited by Robert R. Rich, MD, Professor of Medicine and Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA; Thomas A. Fleisher, MD, FAAAAI, FACAAI, Adjunct Professor of Pediatrics, USUHA, Chief, Department of Laboratory Medicine, NIH Clinical Center, National Institutes of Health, Bethesda MD, USA; Harry W. Schroeder Jr., II, MD, PhD, Professor of Medicine, Microbiology, and Genetics, Division of Clinical Immunology and Rheumatology, Director, UAB Program in Immunology, University of Alabama at Birmingham, Birmingham, AL, USA; Cornelia M. Weyand, MD, PhD, Professor of Medicine, Stanford University School of Medicine, Department of Medicine: Immunology and Rheumatology, Stanford, CA, USA ; David B. Corry and Jennifer M. Puck
Table of Content

PART 1: Epidemiology, Growth and Development

1. Epidemiology and World-wide Impact of Visual Impairment in Children

2. Clinical Embryology and Developmental Biology of the Eye

3. Normal and Abnormal Visual Development

4. Milestones and Normative Data

PART 2: Core Practice

5. Examination, History, and Special Tests in Pediatric Ophthalmology

6. Managing Refractive Errors in Children

7. Visual ElectrPediatric Visual Electrophysiology - objective measurement of visual function

8. Imaging the Child's Eye

9. Orbit and Visual Pathway Imaging

10. Genetics and Pediatric Ophthalmology

PART 3: Infections, Allergic and External Eye Disorders

11. Ocular Manifestations of intrauterine infections

12. Conjunctivitis of the Newborn

13. Preseptal and Orbital Cellulitis

14. Endophthalmitis

15. External Eye Disease and the Oculocutaneous Disorders

PART 4: Systematic Paediatric Ophthalmology

Section A: Disorders of the Eye as a Whole

16. Disorders of the Eye as a Whole

Section B: Lids, Brows and Oculoplastics

17. Lids: Congenital and acquired abnormalities - practical management

18. The Lacrimal System

Section C: Orbit

19. The Management of Orbital Disease in Children

20. Lid and orbital infantile periocular hemangiomas (capillary hemangiomas) and other vascular diseases

21. Neurogenic Tumors of the Orbit

22. Orbital Rhabdomyosarcoma

23. Other Mesenchymal Abnormalities

24. Metastatic, Secondary & Lacrimal Gland Tumors

25. Histiocytic, Haematopoietic and Lymphoproliferative Disorders

26. Craniofacial Abnormalities

27. Cystic Lesions and Ectopias

28. Inflammatory Disorders

Section D: External Disease and Anterior Segment

29. Conjunctiva

30. Conjunctival Tumors

31. Anterior Segment Developmental Anomalies

32. Corneal abnormalities in childhood

33. Corneal surgery

34. The Lens

35. Childhood Cataracts

36. Childhood Glaucoma

Section E: The Uvea

37. Pediatric Iris Disorders

38. Aniridia Syndrome

39. Uveitis

40. Albinism

Section F: Retinal & Vitreous Disorders

41. Vitreous

42. Retinoblastoma

43. Retinopathy of Prematurity: Pathophysiology and screening

44. Current Treatment of Retinopathy of Prematurity

45. Inherited retinal disorders

46. Retinal Dystrophies with Systemic Associations and the Retinal Ciliopathies

47. Inherited Macular Dystrophies

48. Congenital pigmentary and vascular abnormalities of the retina

49. Retinal flecks, dots and crystals

50. Acquired and other retinal disorders (including Juvenile X-Linked Retinoschisis)

51. Retinal Detachment in Childhood

Section G: Neural Visual Systems

52. The Pupil

53. Congenital Anomalies of the Optic Discs

54. Hereditary Optic Neuropathies

55. Other Acquired Optic Disc Abnormalities in Children

56. Demyelinating, Inflammatory, and Infectious Optic Neuropathies

57. The Optic Chiasm

58. Headache in Children

59. Raised Intracranial Pressure

60. The Brain and Cerebral Visual Impairment

PART 5: Selected Topics in Pediatic Ophthalmology

61. Delivering Bad News

62. Common Issues arising in Children with Visual Impairment

63. Visual conversion disorders and fabricated or exaggerated symptoms in children

64. Dyslexia

65. Neurometabolic Disease and the Eye

66. Leukemia

67. Mitochondrial disorders

68. Phakomatoses

69. Neurofibromatosis Type 1 and 2

70. Accidental Trauma in Children

71. Child Maltreatment, Abusive Head Trauma and the Eye

72. Refractive Surgery in Children

PART 6: Amblyopia, Strabismus and Eye Movements

Section A: The Fundamentals of Strabismus and Amblyopia

73. Binocular Vision

74. Amblyopia: the basics, the questions, and the practical management

75. Anatomy of Strabismus

76. The Orthoptic Evaluation

Section B: Esotropias

77. Infantile Esotropias

78. Accommodative Esotropias

79. Special Esotropias (acute comitant, myopia-associated and microtropia)

Section C: Exotropias

80. Intermittent Exotropia

81. Special Forms of Comitant Exotropia

Section D: Vertical, "Pattern" Strabismus and Abnormal Head Postures

82. Vertical Strabismus

83. "A," "V," and other pattern strabismus

Section E: "Neurological" Strabismus

84. Congenital Cranial Dysinnervation Disorders

85. Ocular Motor Nerve Palsies

86. Myasthenia Gravis

Section F: Strabismus Treatment

87. Strabismus: non-surgical treatment

88. Strabismus Surgery

89. Complications in Strabismus Surgery

Section G: Nystagmus and Eye Movements

90. Nystagmus in childhood

91. Supranuclear Eye Movement Disorders: Acquired and Neurological Nystagmus

PART 7: Common Practical Problems in a Paediatric Ophthalmology and Strabismus Practice

92. "I think my baby can't see!"

93. "My baby's got a red eye, doctor!"

94. "My child keeps blinking and closing his eye"

95. "My child seems to hate the bright light"

96. My child's eyes keep watering!"

97. Proptosis at different ages

98. "My child's teacher says she can't see properly!"

99. The child with a dual sensory loss (deafblind)

100. "My little girl tells me she sees strange things"

101. Wobbly Eyes In Infancy

102. Abnormal Head Postures in Children

103. Hand Defects and the Eye

104. Optimizing Compliance In Patching Therapy

105. Vision Screening

Publication Date 23-08-2022
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