Drug Discovery and Development , 2nd Edition

Edited by Raymond G Hill
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  • The definitive introduction to how a pharmaceutical company goes about its business of discovering and developing drugs.

    The second edition has a new editor: Professor Raymond Hill ● non-executive director of Addex Pharmaceuticals, Covagen and of Orexo AB ● Visiting Industrial Professor of Pharmacology in the University of Bristol ● Visiting Professor in the School of Medical and Health Sciences at the University of Surrey ● Visiting Professor in Physiology and Pharmacology at the University of Strathclyde ● President and Chair of the Council of the British Pharmacological Society ● member of the Nuffield Council on Bioethics and the Advisory Council on Misuse of Drugs.

    New to this edition:

    • Completely rewritten chapter on The Role of Medicinal Chemistry in the Drug Discovery Process.
    • New topic - DMPK Optimization Strategy in drug discovery.
    • New chapter on Scaffolds: Small globular proteins as antibody substitutes.
    • Totally updated chapters on Intellectual Property and Marketing
    • 50 new illustrations in full colour



    • Accessible, general guide to pharmaceutical research and development.
    • Examines the interfaces between cost and social benefit, quality control and mass production, regulatory bodies, patent management, and all interdisciplinary intersections essential to effective drug development.
    • Written by a strong team of scientists with long experience in the pharmaceutical industry.
    • Solid overview of all the steps from lab bench to market in an easy-to-understand way which will be accessible to non-specialists.


    From customer reviews of the previous edition:

    '. it will have everything you need to know on this module. Deeply referenced and, thus, deeply reliable.


    • Highly Commended in the medicine category of the BMA 2006 medical book competition
    • Winner of the Royal Society of Medicine Library Prize for Medical Book of the Year
ISBN 9780702042997
Author Information Edited by Raymond G Hill, President, British Pharmacological Society, London, UK
Table of Content




1. The development of the pharmaceutical industry 

H P Rang

2. The nature of disease and the purpose of therapy 

H P Rang, R G Hill

3. Therapeutic modalities 

H P Rang, H LeVine, R G Hill



4. The drug discovery process: general principles and some case histories 

H P Rang, R G Hill

5. Choosing the project 

H P Rang, R G Hill

6. Choosing the target 

H P Rang, R G Hill

7. The role of information, bioinformatics and genomics  

B Robson, R McBurney

8. High-throughput screening 

D Cronk

9. The role of medicinal chemistry in the drug discovery process 

P Beswick, A Naylor

10. DMPK optimization strategy in drug discovery 

P G Ballard, P Brassil, K H Bui, H Dolgos, C Petersson, A Tunek, P J H Webborn

11. Pharmacology: its role in drug discovery 

H P Rang

12. Biopharmaceuticals 

H LeVine

13. Scaffolds: Small globular proteins as antibody substitutes  

D Grabulovski, J Bertschinger



14. Drug development: introduction

H P Rang, R G Hill

15. Assessing drug safety 

H P Rang, R G Hill

16. Pharmaceutical developmentT Lundqvist, S Bredenberg

17. Clinical Development - Present and Future 

C Keywood

18. Clinical imaging in drug development 

P M Matthews

19. Intellectual property in drug discovery and development 

P Grubb

20. Regulatory affairs 

I Hägglöf, Å Holmgren

21. Marketing the drug 

V L Lawton



22. Drug discovery and development - facts and figures 

H P Rang, R G Hill

Publication Date 30-08-2012
Pages 348
Trim 246 X 189 (7 11/16 x 9 7/16)
Stock Status In Stock
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