Fetal and Neonatal Physiology, 2-Volume Set , 5th Edition

By Richard A. Polin, MD, Steven H. Abman, MD, David Rowitch, MD, PhD and William E. Benitz, MD
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    • Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants.
    • Chapters devoted to clinical correlation help explain the implications of fetal and neonatal physiology.
    • Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more.

    Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this 2-volume resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice.

    The 5th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease; Fetal and Neonatal Physiology synthesizes this knowledge into definitive guidance for today's busy practitioner.

    Key Features
      • Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants.
      • Chapters devoted to clinical correlation help explain the implications of fetal and neonatal physiology.
      • Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more.
      ISBN 9780323352147
      Author Informaiton By Richard A. Polin, MD, William T. Speck Professor of Pediatrics, College of Physicians and Surgeons, Columbia University; Director, Division of Neonatology, Morgan Stanley Children's Hospital of New York - Presbyterian, Columbia University Medical Center, New York, New York ; Steven H. Abman, MD, Professor of Pediatrics, University of Colorado School of Medicine; Director, Pediatric Heart Lung Center, Children's Hospital Colorado, Denver, Colorado; David Rowitch, MD, PhD, Professor of Pediatrics and Neurosurgery, Chief, Division of Neonatology, UCSF Benioff Children's Hospital San Francisco, San Francisco, California and William E. Benitz, MD, Philip Sunshine Professor in Neonatology, Chief, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Director of Nurseries, Lucile Packard Children's Hospital, Palo Alto, California
      Published Reviews

      "There are no comparable books in this field and this one should hold a unique place as a reference for both physician scientists and clinicians. The new section on the pathophysiology of neonatal disease adds value to this already incomparable text."

      -Jay P. Goldsmith, MD (Tulane University School of Medicine), Doody's Score: 96 - 4 Stars!

      Table of Content

      Section I - Genetics and Embryology

      1. Basic Genetic Principles
      2. Prenatal Diagnosis
      3. Basic Embryology
      4. Regulation of Embryogenesis
      5. The Extracellular Matrix in Development
      6. Stem Cell Biology
      7. Apoptotic Cell Death
      8. Angiogenesis
      9. Epigenetics
      10. Section II - Placenta and Intrauterine Environment

      11. Placental Development
      12. Regulation of the Placental Circulation
      13. Mechanisms of Transfer Across the Human Placenta
      14. Endocrine and Paracrine Function of the Human Placenta
      15. Fetal and Maternal Responses to Intrauterine Infection
      16. Fetal Origins of Adult Disease: A Classic Hypothesis with New Relevance
      17. Physiologic Effects of Multiple Pregnancy on Mother and Fetus
      18. Placental function in intrauterine growth restriction
      19. Section III - Developmental Pharmacology and Pharmacokinetics

      20. Basic Pharmacologic Principles
      21. Principles of Pharmacokinetics
      22. Physicochemical and Structural Properties Regulating Placental Drug Transfer
      23. Pharmacogenetics
      24. Drug Distribution in Fetal Life
      25. Drug Transfer During Breastfeeding
      26. Section IV - Intrauterine and Postnatal Growth

      27. Circulatory and Metabolic Changes Accompanying Fetal Growth Restriction
      28. Endocrine Factors Affecting Neonatal Growth
      29. Human Milk Composition and Function in the Infant
      30. Physiology of Lactation
      31. Section V - Perinatal Iron, Mineral, and Vitamin Metabolism

      32. Fetal and Neonatal Iron Metabolism
      33. Neonatal Calcium, Phosphorus, and Magnesium Homeostasis
      34. Zinc in the Fetus and Neonate
      35. Vitamin A Metabolism in the Fetus and Neonate
      36. Vitamin E Metabolism in the Fetus and Newborn Infant
      37. Vitamin K Metabolism in the Fetus and Neonate
      38. Section VI - Lipid Metabolism

      39. Maternal-Fetal Transfer of Lipid Metabolites
      40. Brown Adipose Tissue: Development and Function
      41. Lipids as an Energy Source for the Premature and Full-Term Neonate
      42. Ketone Body Production and Metabolism in the Fetus and Neonate
      43. Long-Chain Fatty Acids in the Developing Retina and Brain
      44. Section VII - Carbohydrate Metabolism

      45. Metabolism of Glucose and Methods of Investigation in the Fetus and Newborn
      46. Carbohydrate Metabolism During Pregnancy
      47. Oxygen Consumption and General Carbohydrate Metabolism of the Fetus
      48. Role of Glucoregulatory Hormones in Hepatic Glucose Metabolism During the Perinatal Period
      49. Cell Glucose Transport and Glucose Handling During Fetal and Neonatal Development
      50. Section VIII - Protein Metabolism

      51. General Concepts of Protein Metabolism
      52. Fetal Requirements and Placental Transfer of Nitrogenous Compounds
      53. Section IX - Thermoregulation

      54. Temperature Control in Newborn Infants
      55. Responses of the Fetus and Neonate to Hypothermia
      56. Section X - Skin

      57. Structure and Development of Skin and Cutaneous Appendages
      58. Physiologic Development of the Skin
      59. Section XI - Fetal and Neonatal Cardiovascular Physiology

      60. Cardiovascular Development
      61. Developmental Electrophysiology in the Fetus and Neonate
      62. Developmental Biology of the Pulmonary Vasculature
      63. Development of the Gastrointestinal Circulation in the Fetus and Newborn
      64. Physiology of Congenital Heart Disease in the Neonate
      65. Neural Regulation of Blood Pressure During Fetal and Newborn Life
      66. Developmental Effects on Fetal Circulation
      67. Mechanisms Regulating Closure of the Ductus Arteriosus
      68. Umbilical Circulation
      69. Fetal and Placental Circulation During Labor
      70. Physiology of Resuscitation
      71. Section XII - The Lung

      72. Normal and Abnormal Structural Development of the Lung
      73. Regulation of Alveolarization
      74. Physiologic Mechanisms of Normal and Altered Lung Growth Before and After Birth
      75. Molecular Mechanisms of Lung Development and Lung Branching Morphogenesis
      76. Regulation of Liquid Secretion and Absorption by the Fetal and Neonatal Lung
      77. Upper Airway Structure: Function, Regulation, and Development
      78. Regulation of Lower Airway Function
      79. Functional Development of Respiratory Muscles
      80. Mechanics of Breathing
      81. Pulmonary Gas Exchange in the Developing Lung
      82. Oxygen Transport and Delivery
      83. Control of Breathing in Fetal Life and Onset and Control of Breathing in the Neonate
      84. Basic Mechanisms of Oxygen Sensing and Response to Hypoxia
      85. Evaluation of Pulmonary Function in the Neonate
      86. Mechanisms of Neonatal Lung Injury
      87. Impaired Lung Growth After Injury in Premature Lung
      88. Antenatal Factors That Influence Postnatal Lung Development and Injury
      89. Regulation of Pulmonary Circulation
      90. Section XIII - Surfactant

      91. Historical Perspective
      92. Composition of Pulmonary Surfactant Lipids and Proteins
      93. Structure And Development of Alveolar Epithelial Cells
      94. Regulation of Surfactant-Associated Phospholipid Synthesis and Secretion
      95. Hormonal Therapy for Prevention of Respiratory Distress Syndrome
      96. Surfactant Treatment
      97. Genetics and Physiology of Surfactant Protein Deficiencies
      98. Section XIV - Physiology of Gastrointestinal Tract in the Fetus and Neonate

      99. Trophic Factors and Regulation of Gastrointestinal Tract and Liver Development
      100. Organogenesis of the Gastrointestinal Tract
      101. Development of the Enteric Nervous System
      102. Development of Gastric Secretory Function
      103. Development of Gastrointestinal Motility
      104. Development of the Exocrine Pancreas
      105. Digestive-Absorption Functions in Fetuses, Infants, and Children
      106. Development of the Intestinal Microbiome
      107. Section XV - Liver and Bilirubin Metabolism

      108. Organogenesis and Histologic Development of the Liver
      109. Bile Acid Metabolism During Development
      110. Neonatal Bilirubin Metabolism
      111. Hereditary Contribution to Neonatal Hyperbilirubinemia
      112. Mechanisms of Action of Phototherapy for Neonatal Hyperbilirubinemia
      113. Section XVI - The Kidney

      114. Embryogenesis and Anatomic Development of the Kidney
      115. Functional Development of the Kidney in Utero
      116. Development and Regulation of Renal Blood flow in the Neonate
      117. Development of the Renin-Angiotensin System
      118. Postnatal Development of Glomerular Filtration Rate in Neonates
      119. Renal Transport of Sodium During Early Development
      120. Potassium Homeostasis in the Fetus and Neonate
      121. Role of the Kidney in Calcium and Phosphorus Homeostasis
      122. Transport of Amino Acids in the Fetus and Neonate
      123. Developmental Aspects of Organic Acid Transport
      124. Concentration and Dilution of the Urine
      125. Development of Acidification Mechanisms in the Fetus and Neonate
      126. Response to Nephron Loss in Early Development
      127. Section XVII - Fluid and Electrolyte Metabolism

      128. Fluid Distribution in the Fetus and Neonate
      129. Regulation of Acid-Base Balance in the Fetus and Neonate
      130. Section XVIII - Developmental Hematopoiesis

      131. Developmental Biology of Stem Cells: From the Embryo to the Adult
      132. Developmental Granulocytopoiesis
      133. Developmental Erythropoiesis
      134. Developmental Megakaryocytopoiesis
      135. Section XIX - Hemostasis

      136. Developmental Hemostasis
      137. Platelet-Vessel Wall Interactions
      138. Section XX - Developmental Immunobiology

      139. Host Defense Mechanisms Against Bacteria
      140. Host-Fungi Interactions Relevant to the Newborn Infant
      141. Host Defense Mechanisms Against Viruses
      142. T-Cell Development
      143. B-Cell Development
      144. Mononuclear Phagocyte System
      145. Normal and Abnormal Neutrophil Physiology in the Newborn
      146. The Complement System of the Fetus and Newborn
      147. Cytokines and Inflammatory Response in the Fetus and Neonate
      148. Immunology of Human Milk and Host Immunity
      149. Neonatal Pulmonary Host Defense
      150. Section XXI - Neurology

      151. Development of the Nervous System
      152. Development of the Blood-Brain Barrier
      153. Trophic Factor and Nutritional and Hormonal Regulation of Brain Development
      154. Intraventricular Hemorrhage in the Neonate
      155. Cerebellar Development - an Impact of Preterm Birth and Co-Morbidities
      156. Electroencephalography in the Premature and Full-Term Infant
      157. Developmental Aspects of Pain
      158. Section XXII - Special Sensory Systems in the Fetus and Neonate

      159. Early Development of the Human Auditory System
      160. Development of Taste and Smell in the Neonate
      161. Section XXIII - Orthopedics

      162. The Growth Plate: Embryologic Origin, Structure, and Function
      163. Ontogenesis of Striated Muscle
      164. Section XXIV - Endocrine Function

      165. Hypothalamus: Neuroendometabolic Center
      166. Growth Factor Regulation of Fetal Growth
      167. Growth Hormone in the Fetus and Newborn
      168. Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in the Fetus and Newborn
      169. Development of the Corticotropin-Releasing Hormone-Corticotropin System in the Mammalian Fetus
      170. Fetal and Neonatal Adrenocortical Physiology
      171. Fetal and Neonatal Thyroid Physiology
      172. Section XXV - Ovary and Testis

      173. Genetics of Sex Determination and Differentiation
      174. Differentiation of the Ovary
      175. Testicular Development and Descent
      176. Section XXVI - Pathophysiology of Neonatal Diseases

      177. Pathophysiology of Neonatal sepsis
      178. Pathophysiology of Hypoglycemia in the Neonate
      179. Pathophysiology of Cardiomyopathies
      180. Pathophysiology of Persistent pulmonary hypertension of the newborn
      181. Pathophysiology of Shock in the Fetus and Neonate
      182. Pathophysiology of Apnea of Prematurity
      183. Pathophysiology of Respiratory Distress Syndrome
      184. Pathophysiology of Meconium Aspiration Syndrome
      185. Pathophysiology of Bronchopulmonary Dysplasia
      186. Pathophysiology of Ventilator Dependent Infants
      187. Pathophysiology of Gastroesophageal Reflux
      188. Pathophysiology of Neonatal Necrotizing Enterocolitis
      189. Pathophysiology of Kernicterus
      190. Pathophysiology of neonatal acute kidney injury
      191. Pathophysiology of Edema
      192. Pathophysiology of Retinopathy of Prematurity
      193. Pathophysiology of Hypoxic-ischemic Brain Injury
      194. Pathophysiology of Neonatal White Matter Injury
      195. Pathophysiology of Meningitis
      196. Pathophysiology of Neural Tube Defects
      197. Pathophysiology of Preeclampsia
      198. Pathophysiology of Preterm Birth
      199. Pathophysiology of Chorioamnionitis
      Publication Date 01-07-2016
      Pages 1852
      Trim 276 x 216 (8 1/2 x 10 7/8)
      Stock Status In Stock
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