細胞生物学, 4th Edition
Reader-friendly Cell Biology, 4th Edition, provides a concise but comprehensive foundation for students entering research or health care career paths. Award winning illustrations help readers quickly grasp general principles. The authors have thoroughly updated this popular text to provide readers with the current understanding of the principles of normal cellular function along with examples of how molecular defects predispose to human disease. Major new themes in the 4th edition include the roles of intrinsically disordered polypeptides and phase separation in cellular functions, the influence of new molecular structures on understanding mechanisms, and the impact of exciting new methods-from single cell RNA sequencing to second generation super resolution fluorescence microscopy-on advancing our understanding.
Clear, readable explanations provide a concise story about how cells function at the molecular level.
An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology.
Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases.
Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation.
Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death.
Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
|Author Information||By Thomas D. Pollard, MD, Sterling Professor, Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT; William C. Earnshaw, PhD, FRS, Professor and Wellcome Trust Principal Research Fellow, Wellcome Trust Centre for Cell Biology, ICB, University of Edinburgh, Scotland, United Kingdom; Jennifer Lippincott-Schwartz, PhD, Group Leader, Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, Virginia, United States and Graham Johnson, MA, PhD, CMI, Director, Animated Cell, Allen Institute for Cell Biology, Seattle, Washington;, QB3 Faculty Fellow, University of California, San Francisco, San Francisco, California|
|Table of Content|| Front Matter/Back Matter/Section Openers
1 Introduction to Cells
2 Evolution of Life on Earth
3 Molecules: Structures and Dynamics
4 Biophysical Principles
5 Macromolecular Assembly
6 Research Strategies
7 Chromosome Organization
8 DNA Packaging in Chromatin and Chromosomes
9 Nuclear Structure and Dynamics
10 Gene Expression
11 Eukaryotic RNA Processing
12 Protein Synthesis and Folding
13 Membrane Structure and Dynamics
14 Membrane Pumps
15 Membrane Carriers
16 Membrane Channels
17 Membrane Physiology
18 Posttranslational Targeting of Proteins
19 Mitochondria, Chloroplasts, Peroxisomes
20 Endoplasmic Reticulum
21 Mechanisms of Vesicular Trafficking
22 Secretory Membrane System and Golgi Appartus
23 Endocytosis and Endosomal Membrane System
24 Processing and Degradation of Cellular Components
25 Plasma Membrane Receptors
26 Protein Hardware for Signaling
27 Second Messengers
28 Integration of Signals
29 Cells of the Extracellular Matrix and Immune System
30 Extracellular Matrix Molecules
31 Cellular Adhesion
32 Intercellular Junctions
33 Connective Tissues
34 Actin and Actin-Binding Proteins
35 Microtubules and Centrosomes
36 Intermediate Filaments
37 Motor Proteins
38 Intracellular Motility
39 Cellular Motility
41 Introduction to the Cell Cycle
42 G1 Phase and Regulation of Cell Proliferation
43 S Phase and DNA Replications
44 G2 Phase, Responses to DNA Damage, and Control of Entry into Mitosis
48 Programmed Cell Death
|trim||276 x 216 (8 1/2 x 10 7/8)|